BENDAMUSTINE HYDROCHLORIDE

Synonyms. Bendamustine hydrochloride; Cytostasan; Ribomustin; Treanda; gamma(1- Methyl-5 -bis(beta-chloraethyl)aminobenzimidazoyl-2)buttersaeurehydrochlorid; 1-Methyl- 5-bis(2-chloroethyl) amino-2-benzimidazolinebutryric acid hydrochloride; omega-(1-Methyl-5- bis(beta- chloroethyl) aminobenzimidazole-(2)-butyric acid hydrochloride;

BENDAMUSTINE

Click for original image

 

PRODUCT IDENTIFICATION

CAS RN

16506-27-7 (net), 3543-75-7 (hydrochloride)

EINECS RN

  

FORMULA

C16H21Cl2N3O2·HCl

MOLE WEIGHT

 394.72

H.S CODE

 2933.99.7500

SMILES

 c12n(C)c(CCCC(=O)O)nc1cc(N(CCCl)CCCl)cc2.Cl

CLASSIFICATION

Antineoplastic agent, Alkylating agent

EXTRA NOTES

 Treatment of hematologic cancer, especially non-Hodgkin's lymphoma
Bendamustine hydrochloride is a DNA-alkylator with a distinct pattern of activity. Bendamustine activates DNA-damage stress response and apoptosis; inhibits mitotic checkpoints; and induces mitotic catastrophe. (SigmaAldrich)

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE.

white to off-white powder

MELTING POINT

152 ~ 156 C

BOILING POINT

 

DENSITY

 

SOLUBILITY IN WATER

Soluble

SOLVENT SOLUBILITY Soluble in Methanol

VAPOR DENSITY

 

log P(octanol-water)

  

VAPOR PRESSURE

  

AUTOIGNITION TEMP

  
pKa

 

REFRACTIVE INDEX

 

FLASH POINT

267 C

 

STABILITY AND REACTIVITY
STABILITY Stable under normal conditions.

INCOMPATIBLE MATERIALS

Strong oxidizing agents

POLYMERIZATION

Has not been reported

NFPA RATINGS

Health: 2, Flammability:0, Reactivity: 0

 

EXTERNAL LINKS & GENERAL DESCRIPTION

Wikipedia Linking - Bendamustine

Google Scholar Search - Bendamustine

Drug Information Portal (U.S. National Library of Medicine) - Bendamustine hydrochloride

PubChem Compound Summary - Bendamustine hydrochloride

Drug Bank -  Bendamustine

KEGG (Kyoto Encyclopedia of Genes and Genomes) - Bendamustine

http://www.ebi.ac.uk/ - Bendamustine

http://www.ncbi.nlm.nih.gov/ - Bendamustine

http://toxnet.nlm.nih.gov/
Hazardous Substances Data Bank -  Bendamustine

http://www.bccancer.bc.ca/
MECHANISM OF ACTION: Bendamustine is a bifunctional mechlorethamine derivative containing a purine-like benzimidazole ring. Its exact mechanism of action is unknown, but it may cause apoptotic and non-apoptotic death of malignant cells by damaging both single- and double-strand DNA, increasing the expression of pro-apoptotic genes, and inhibiting mitotic control. Bendamustine is active against both quiescent and dividing cells...

 

SALES SPECIFICATION

APPEARANCE

white to off-white powder

IDENTIFICATION

positive ( HPLC, IR)

ASSAY

98.5% min

MELTING POINT

152 ~ 156 C

IMPURITY

2.0% max (total), 0.5% max (Individual)

CLARITY

clear

RESIDUE ON IGNITION

0.5% max

HEAVY METALS

20ppm max

 

TRANSPORT & REGULATORY INFORMATION

UN NO.

2811

HAZARD CLASS

 6.1
PACKING GROUP III

 

SAFETY INFORMATION

HAZARD OVERVIEW

Toxic if swallowed. Suspected of causing cancer. May damage fertility or the unborn child. OSHA Hazards:Toxic by ingestion, Carcinogen, Teratogen

GHS

  

SIGNAL WORD

Danger

PICTOGRAMS

HAZARD STATEMENTS

H301-H351-H360

P STATEMENTS

P201-P281-P301 + P310-P308 + P313

EC DIRECTIVES

 

HAZARD CODES

T

RISK PHRASES

 60-61-22-40

SAFETY PHRASES

 36-37

 

PACKING